Arrowsmith

leaving Zenith, the excitement of the journey to Wheatsylvania, the scramble of his state examinations, the dignity of being a Practicing Physician, he forgot Gottlieb, and on that Dakota prairie radiant in early June, with meadow larks on every fence post, he began his work.

XII

I
At the moment when Martin met him on the street, Gottlieb was ruined.
Max Gottlieb was a German Jew, born in Saxony in 1850. Though he took his medical degree, at Heidelberg, he was never interested in practicing medicine. He was a follower of Helmholtz, and youthful researches in the physics of sound convinced him of the need of the quantitative method in the medical sciences. Then Koch’s discoveries drew him into biology. Always an elaborately careful worker, a maker of long rows of figures, always realizing the presence of uncontrollable variables, always a vicious assailant of what he considered slackness or lie or pomposity, never too kindly to well-intentioned stupidity, he worked in the laboratories of Koch, of Pasteur, he followed the early statements of Pearson in biometrics, he drank beer and wrote vitriolic letters, he voyaged to Italy and England and Scandinavia, and casually, between two days, he married (as he might have bought a coat or hired a housekeeper) the patient and wordless daughter of a Gentile merchant.
Then began a series of experiments, very important, very undramatic-sounding, very long, and exceedingly unappreciated. Back in 1881 he was confirming Pasteur’s results in chicken cholera immunity and, for relief and pastime, trying to separate an enzyme from yeast. A few years later, living on the tiny inheritance from his father, a petty banker, and quite carelessly and cheerfully exhausting it, he was analyzing critically the ptomain theory of disease, and investigating the mechanism of the attenuation of virulence of microorganisms. He got thereby small fame. Perhaps he was overcautious, and more than the devil or starvation he hated men who rushed into publication unprepared.
Though he meddled little in politics, considering them the most repetitious and least scientific of human activities, he was a sufficiently patriotic German to hate the Junkers. As a youngster he had a fight or two with ruffling subalterns; once he spent a week in jail; often he was infuriated by discriminations against Jews: and at forty he went sadly off to the America which could never become militaristic or antisemitic⁠—to the Hoagland Laboratory in Brooklyn, then to Queen City University as professor of bacteriology.
Here he made his first investigation of toxin-anti-toxin reactions. He announced that antibodies, excepting antitoxin, had no relation to the immune state of an animal, and while he himself was being ragingly denounced in the small but hectic world of scientists, he dealt calmly and most brutally with Yersin’s and Marmorek’s theories of sera.
His dearest dream, now and for years of racking research, was the artificial production of antitoxin⁠—its production in vitro. Once he was prepared to publish, but he found an error and rigidly suppressed his notes. All the while he was lonely. There was apparently no one in Queen City who regarded him as other than a cranky Jew catching microbes by their little tails and leering at them⁠—no work for a tall man at a time when heroes were building bridges, experimenting with Horseless Carriages, writing the first of the poetic Compelling Ads, and selling miles of calico and cigars.
In 1899 he was called to the University of Winnemac, as professor of bacteriology in the medical school, and here he drudged on for a dozen years. Not once did he talk of results of the sort called “practical”; not once did he cease warring on the post hoc propter hoc conclusions which still make up most medical lore; not once did he fail to be hated by his colleagues, who were respectful to his face, uncomfortable in feeling his ironic power, but privily joyous to call him Mephisto, Diabolist, Killjoy, Pessimist, Destructive Critic, Flippant Cynic, Scientific Bounder Lacking in Dignity and Seriousness, Intellectual Snob, Pacifist, Anarchist, Atheist, Jew. They said, with reason, that he was so devoted to Pure Science, to art for art’s sake, that he would rather have people die by the right therapy than be cured by the wrong. Having built a shrine for humanity, he wanted to kick out of it all mere human beings.
The total number of his papers, in a brisk scientific realm where really clever people published five times a year, was not more than twenty-five in thirty years. They were all exquisitely finished, all easily reduplicated and checked by the doubtfulest critics.
At Mohalis he was pleased by large facilities for work, by excellent assistants, endless glassware, plenty of guinea pigs, enough monkeys; but he was bored by the round of teaching, and melancholy again in a lack of understanding friends. Always he sought someone to whom he could talk without suspicion or caution. He was human enough, when he meditated upon the exaltation of doctors bold through ignorance, of inventors who were but tinkers magnified, to be irritated by his lack of fame in America, even in Mohalis, and to complain not too nobly.
He had never dined with a duchess, never received a prize, never been interviewed, never produced anything which the public could understand, nor experienced anything since his schoolboy amours which nice people could regard as romantic. He was, in fact, an authentic scientist.
He was of the great benefactors of humanity. There will never, in any age, be an effort to end the great epidemics or the petty infections which will not have been influenced by Max Gottlieb’s researches, for he was not one who tagged and prettily classified bacteria and protozoa. He sought their chemistry, the laws of their existence and destruction, basic laws for the most part unknown after a generation of busy biologists. Yet they were right who called him “pessimist,” for this man who, as much as any other, will have been the cause of reducing infectious diseases to almost-zero